Hydrochloric Acid → Bis(3,5-dimethylphenyl)-(4-fluorophenyl)-sulfonium bromide

Participants

Reaction Steps

To a Grignard reagent prepared from 79 g of 1-bromo-4-fluorobenzene, 13 g of bis(3,5-dimethylphenyl) sulfoxide obtained in Synthesis Example 1-46 and 50 g of methylene chloride were added. Under ice cooling, 16 g of trimethylsilyl chloride was added dropwise to the solution, which was aged for 30 minutes. To the reaction solution, 50 g of 3 wt % dilute hydrochloric acid was added to quench the reaction. The organic layer was separated. Without further purification, it was ready for use in the subsequent reaction.

Provenance & Evidence