Hydrochloric Acid → HCID 57775920, compound

Participants

Reaction Steps

To a solution of Boc-L-Threonine (0.44 g 2.0 mmol) in 10.0 ml of DCM was added crotyl chloride (0.32 g, 3.0 mmol) at RT followed by the addition of catalytic amount of DMAP and TEA (1.0 ml, 6 mmol). The reaction mixture was stirred for 10 h at RT. Aqueous NaHCO3 solution (10 mL) was added to quench the reaction. After 2 hours, 1N HCl aqueous solution was added slowly to PH˜3. The DCM layer was collected and the aqueous was extracted by DCM (2×10 mL). The organic layer was dried over Na2SO4, filterd and the solvent was removed to provide the crude product.

Provenance & Evidence