反应详情

温度

110 °C

A mixture of 3.42 g (10 mmol) of 3,7-dibromodibenzo[b,d]thiophene, 5.5 g (24 mmol) of 5-methoxybiphenyl-2-ylboronic acid, 0.12 g (0.1 mmol) of tetrakis(triphenylphosphine)palladium, 15 ml of 2M Na2CO3, 20 ml of EtOH and 60 ml toluene was degassed and placed under nitrogen, then heated at 110° C. for 8 h. After finishing the reaction, the mixture was allowed to cool to room temperature. The reaction mixture was extracted with ethyl acetate and water, dried with anhydrous magnesium sulfate, the solvent was evaporated in vacuum. The residue was purified by column chromatography on silica(hexane-dichloromethane) to afford a white solid (4.4 g, 8.1 mmol, 81%).

1. customwas degassed
2. customthe reaction
3. temperatureto cool to room temperature
4. extractionThe reaction mixture was extracted with ethyl acetate and water
5. dry with materialdried with anhydrous magnesium sulfate
6. customthe solvent was evaporated in vacuum
7. customThe residue was purified by column chromatography on silica(hexane-dichloromethane)