3-Fluorobenzyl bromide → HCID 54766583, compound

HRID 1753752Notes

Reaction equation

HRID 1753752 reaction equation
[CH3:1][C:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([OH:15])[CH:11]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1.Br[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=1>>[CH3:1][C:2]1[C:14]2[N:13]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=4)[CH:11]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 178432657HCID 178432657, compound

Product 1

HCID 54766583HCID 54766583, compoundYield 85%

Procedure

The title compound was synthesized from 1-methyl-7-hydroxy-β-carboline (0.5 g, 1.587 mmol) in presence of 1-bromomethyl-3-fluorobenzene (0.6 g, 3.173 mmol) as described here above.

Sources & evidence

ORD record
ord-88d38c93ab6a4167aa489bf3e53a6ea8
Source dataset
uspto-grants-2015_10
Patent number
US09168247B2

Reaction notes

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