Hydrochloric Acid → HCID 71241085, compound

Participants

Reaction Steps

3-{3-[2-(3,5-Dimethoxy-phenylamino)-oxazol-5-yl]-phenyl}-1H-pyridin-2-one 219 was prepared as for intermediate I-f above from 3-[3-(2-chloro-oxazol-5-yl)-phenyl]-2-methoxy-pyridine VI-c (40 mg, 0.150 mmol) with 3,5-dimethoxyaniline (29 mg, 0.190 mmol) and HCl (2M in ether, 120 μL, 0.23 mmol) in iPrOH (4 mL). The crude reaction mixture was evaporated under reduced pressure and the residue treated with a saturated solution of NaHCO3 and EtOAc. A precipitate formed from the biphasic mixture and was filtered off and dried to give the compound 219 product as a beige solid (19 mg, 33%). 1H NMR (300 MHz, DMSO-d6) δ 11.86 (s, 1H), 10.35 (s, 1H), 7.96 (s, 1H), 7.70 (dd, J=2.0, 6.9 Hz, 1H), 7.60-7.41 (m, 5H), 6.89 (d, J=2.0 Hz, 2H), 6.32 (t, J=6.7 Hz, 1H), 6.13 (s, 1H), 3.73 (s, 6H). ESI+ MS m/z 390 (M+H)+. Retention time=3.45 min (method 1).

Provenance & Evidence