Ammonia → HCID 56960208, compound

Participants

Reaction Steps

A mixture compound 3 (0.2 g) and NH3 (7N in MeOH, 10 mL) was heated to 50° C. for 14 hours. After cooling to room temperature, the reaction was titrated with water, and the solid was collected, washed with water and dried to obtain compound 5 as a white solid (0.11 g, yield 60%): 1H-NMR (400 MHz, CDCl3): δ 8.34 (d, 1H, 8.3 Hz), 8.25 (d, 1H, 8.3 Hz), 8.15 (br, 1H, NH), 8.01 (dt, 1H, 1.3 & 8.1 Hz), 7.86 (d, 2H, 8.9 Hz), 7.73 (dt, 1H, 1.3 & 8.1 Hz), 7.39-7.44 (m, 2H), 7.13-7.23 (m, 5H), 5.99 (br, 1H, NH); LC/MS: m/z=342.5 [M+H]+(Calc: 341.4).

Provenance & Evidence