HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1753800Generated: October 29, 2026
Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine
https://huagongshe.com/reaction/1753800
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(6-Chloropyrimidin-4-yl)morpholine | HCID 796070 | — |
Reaction Steps
45.0 g (302.1 mmol) 4,6-dichloropyrimidine are initially introduced into 450 ml water. 26.3 g (302.1 mmol) morpholine are added and the mixture is stirred at 90° C. for 16 h. Thereafter, it is cooled to 0° C. and the precipitate formed is filtered off. The precipitate is washed once with 50 ml water and dried in air.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09168249B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-a13e757b5cc64d839a946850d1e0b303 |
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| Source note | uspto-grants-2015_10 |
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