Dimethylformamide diethylacetal → 3-(Dimethylamino)-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]acrylic acid ethyl ester

HRID 1753815Notes

Reaction equation

HRID 1753815 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[CH:7]1)[CH3:2].C(O[CH:19](OCC)[N:20]([CH3:22])[CH3:21])C>>[CH2:1]([O:3][C:4](=[O:15])[C:5]([N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:12])[F:13])[N:8]=[CH:7]1)=[CH:19][N:20]([CH3:22])[CH3:21])[CH3:2]

Participants

3

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 59603647[4-(Trifluoromethyl)-1H-imidazol-1-yl]acetic acid ethyl ester

Product 1

HCID 674569553-(Dimethylamino)-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]acrylic acid ethyl ester

Procedure

38.0 g (170.8 mmol) of the compound from Example 32A and 58.5 ml (50.3 g, 341.6 mmol) dimethylformamide diethyl acetal are stirred at a bath temperature of 100° C. for 16 h. For working up, the cooled reaction solution is concentrated on a rotary evaporator and the residue is dried in vacuo.

Workup

  1. customthe cooled reaction solution
  2. concentrationis concentrated on a rotary evaporator
  3. customthe residue is dried in vacuo

Sources & evidence

ORD record
ord-297d59f3dcd64ef38d8b1e9b2ea6162d
Source dataset
uspto-grants-2015_10
Patent number
US09168249B2

Reaction notes

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