tert-Butyl bromoacetate → HCID 58539864, compound

HRID 1753966Notes

Reaction equation

HRID 1753966 reaction equation
C(OC(=O)C[N:6]1[N:10]=[N:9][C:8]([C:11]2[S:15][C:14]([Br:16])=[N:13][CH:12]=2)=[N:7]1)C.Br[CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21]>>[C:23]([O:22][C:20](=[O:21])[CH2:19][N:10]1[N:6]=[N:7][C:8]([C:11]2[S:15][C:14]([Br:16])=[N:13][CH:12]=2)=[N:9]1)([CH3:26])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 58042988HCID 58042988, compound2×

Product 1

HCID 58539864HCID 58539864, compound

Procedure

This compound was synthesized in a similar manner as described for ethyl[5-(2-bromo-1,3-thiazol-5-yl)-2H-tetrazol-2-yl]acetate (INTERMEDIATE 2) using tert-butyl bromoacetate in place of ethyl bromoacetate in step 4. 1H NMR (CDCl3, 400 MHz) 8.22 (1H, s), 5.32 (2H, s), 1.47 (9H, s). MS (ESI, Q+) m/z 346, 348 (M+1, 79Br, 81Br).

Workup

  1. customThis compound was synthesized in a similar manner

Sources & evidence

ORD record
ord-75b298f3d9ed468eae84b0ce035b2a3b
Source dataset
uspto-grants-2015_10
Patent number
US09168248B2

Reaction notes

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