Pyrrolidine → HCID 68753644, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 8-chloro-4-oxo-3,4-dihydro-1′H-spiro[chromene-2,4′-piperidine]-1′-carboxylate A mixture of 1-(3-chloro-2-hydroxyphenyl)ethanone (500 mg, 2.93 mmol), 1-boc-4-piperidone (584 mg, 2.93 mmol) and pyrrolidine (61 pt, 0.738 mmol) in Xylene (4 mL) was heated to 100° C. for 20 h. The reaction mixture was purified by column chromatography on SiO2 (40 g, gradient from 0 to 40% EtOAc/hexanes) to afford the title compound as a white solid. LC-MS: m/z=376.1, 374.1 (M+Na).

Provenance & Evidence