Ethyl isocyanatoacetate → HCID 59571598, compound

Participants

Reaction Steps

Ethyl N-{[(2,2-dimethoxyethyl)amino]carbonyl}glycinate To a solution of ethyl isocyanatoacetate (8.84 mL, 77 mmol) in CH2Cl2 (100 mL) at 0° C. was added aminoacetaldehyde dimethyl acetal (8.86 mL, 81 mmol) over a period of 10 min. The mixture was further stirred for 30 min, quenched with water. The CH2Cl2 layer was separated, washed with water, dried (Na2SO4) and concentrated to give the crude title compound as an oil.

Provenance & Evidence