HCID 86720214, compound → HCID 86720219, compound

Participants

Reaction Steps

The above-described method (Example 2) was repeated to react hexyl 2-amino-5-bromo-3-methylbenzoate (2.2 g, 6.79 mmol) with copper cyanide (0.62 g, 6.93 mmol) in N,N-dimethylacetamide at 170° C. for 6 hours. Following working up similar to Example 2 and additional extraction with ethyl acetate and washing with aqueous 5% ethylenediamine solution, hexyl 2-amino-5-cyano-3-methylbenzoate (1.66 g, 85.5% of theory, 91.1 area % LC) was obtained as a brown oil.

Provenance & Evidence