HCID 86720215, compound → HCID 86720220, compound

Participants

Reaction Steps

The above-described method (Example 2) was repeated to react 2-ethylhexyl 2-amino-5-bromo-3-methylbenzoate (2.00 g, 5.84 mmol) with copper cyanide (0.53 g, 5.96 mmol) in N,N-dimethylacetamide at 160° C. for 8 hours. Following working up similar to Example 2 and additional washing with aqueous 5% ethylenediamine solution, 2-ethylhexyl 2-amino-5-cyano-3-methylbenzoate (1.45 g, 76.7% of theory, 89.1 area % LC) was obtained as a brown oil.

Provenance & Evidence