Methylamine → 2-Amino-5-cyano-N,3-dimethylbenzamide

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Reaction Steps

The above-described method (Example 3) was repeated to stir pentyl 2-amino-5-cyano-3-methylbenzoate (1.50 g, mmol) with methylamine (10.8 g, mmol, 40% in methanol) and sodium methoxide (441 mg, 0.12 mmol, 30% in methanol) at room temperature for 18 hours. The entire reaction batch was vacuum distilled and stirred with diisopropyl ether. 2-Amino-5-cyano-N,3-dimethylbenzamide (0.79 g, 70.6% of theory, 96.4 area % LC) was obtained as a brown solid.

Provenance & Evidence