Methylamine → 2-Amino-5-cyano-N,3-dimethylbenzamide

Participants

Reaction Steps

The above-described method (Example 3) was repeated to stir hexyl 2-amino-5-cyano-3-methylbenzoate (1.40 g, 4.89 mmol) with methylamine (10.8 g, 139 mmol, 40% in methanol) and sodium methoxide (441 mg, 0.12 mmol, 30% in methanol) at room temperature for 18 hours. The entire reaction batch was vacuum distilled and stirred with diisopropyl ether. 2-Amino-5-cyano-N,3-dimethylbenzamide (0.75 g, 75.8% of theory, 93.6 area % LC) was obtained as a brown solid.

Provenance & Evidence