Methylamine → 2-Amino-5-cyano-N,3-dimethylbenzamide

Participants

Reaction Steps

The above-described method (Example 3) was repeated to stir 2-ethylhexyl 2-amino-5-cyano-3-methylbenzoate (1.00 g, 3.09 mmol) with methylamine (3.60 g, 46.3 mmol, 40% in methanol) and one drop of sodium methoxide (30% in methanol) at room temperature for 18 hours. The entire reaction batch was vacuum distilled and 2-amino-5-cyano-N,3-dimethylbenzamide (730 mg, 91.4% of theory, 73.1 area % LC) was obtained as a brown solid.

Provenance & Evidence