Methylamine → 2-Amino-5-cyano-N,3-dimethylbenzamide

Participants

Reaction Steps

The above-described method (Example 3) was repeated to stir ethyl 2-amino-5-cyano-3-methylbenzoate (0.50 g, 2.40 mmol) with methylamine (3.73 g, 48 mmol, 40% in methanol) and sodium methoxide (22 mg, 30% in methanol) at room temperature for 18 hours. The entire reaction batch was vacuum distilled and 2-amino-5-cyano-N,3-dimethylbenzamide (0.44 g, 95.9% of theory, 99.0 area % LC) was obtained as a pale brown solid.

Provenance & Evidence