Methylamine → 2-Amino-5-cyano-N,3-dimethylbenzamide

Participants

Reaction Steps

The above-described method (Example 3) was repeated to stir 2-methoxyethyl 2-amino-5-cyano-3-methylbenzoate (200 mg, 0.81 mmol) with methylamine (5.40 g, 69.5 mmol, 40% in methanol) and one drop of sodium methoxide (30% in methanol) at room temperature for 18 hours. The entire reaction batch was vacuum distilled and following purification by column chromatography, 2-amino-5-cyano-N,3-dimethylbenzamide (150 mg, 95.0% of theory, 97.8 area % LC) was obtained as a pale brown solid.

Provenance & Evidence