Perchloric Acid → HCID 178486413, compound

Participants

Reaction Steps

To a mixture of 5-amino-1H-pyrazole-4-carbonitrile (193 mg, 1.79 mmol) and 6-methoxy-2,3-dihydro-1H-indene-5-carbaldehyde (315 mg, 1.79 mmol) in a vial under nitrogen atmosphere were added methanol (10 mL) followed by cyclopentyl isonitrile (172 mg, 200 μL, 1.79 mmol) and perchloric acid (35.9 mg, 32.1 μL, 0.358 mmol) at RT. Then, the resulting light yellow suspension was stirred for 15 h and the resulting solids were collected by filtration and washed with methanol. After air drying, 55 mg (8.5% yield) of 3-(cyclopentylamino)-2-(6-methoxy-2,3-dihydro-1H-inden-5-yl)-1H-imidazo[1,2-b]pyrazole-7-carbonitrile was isolated as an off-white solid. LC/MS calcd. for C21H23N5O (m/e) 361.44, obsd. 362.1 (M+H, ES+).

Provenance & Evidence