Perchloric Acid → HCID 178489027, compound

Participants

Reaction Steps

To a mixture of 5-amino-1H-pyrazole-4-carbonitrile (491 mg, 4.54 mmol) and 2,4-dimethoxybenzaldehyde (754 mg, 4.54 mmol) in a vial under nitrogen atmosphere were added methanol (20 mL) followed by cyclohexyl isonitrile (500 mg, 581 μL, 4.54 mmol) and perchloric acid (91.2 mg, 81.4 μL, 0.908 mmol) at RT. Then, the resulting brown solution was stirred for 15 h by which time lots of solid was formed. These solids were collected by filtration and washed with methanol. After air drying, 495 mg (30% yield) of 3-(cyclohexylamino)-2-(2,4-dimethoxyphenyl)-1H-imidazo[1,2-b]pyrazole-7-carbonitrile was isolated as a white solid. LC/MS calcd. for C20H23N5O2 (m/e) 365.43, obsd. 366.0 (M+H, ES+).

Provenance & Evidence