Perchloric Acid → HCID 178493377, compound

Participants

Reaction Steps

To a mixture of 5-amino-1H-pyrazole-4-carbonitrile (193 mg, 1.79 mmol) and 4-(benzyloxy)-2-methoxybenzaldehyde (433 mg, 1.79 mmol) in a vial under nitrogen atmosphere were added methanol (10 mL) followed by cyclopentyl isonitrile (172 mg, 200 μL, 1.79 mmol) and perchloric acid (35.9 mg, 32.1 μL, 0.358 mmol) at RT. Then, the resulting brown solution was stirred for 15 h by which time lot of solids precipitated. These solids were collected by filtration and washed with methanol. After air drying, 320 mg of (42%) 2-(4-benzyloxy-2-methoxyphenyl)-3-(cyclopentylamino)-1H-imidazo[1,2-b]pyrazole-7-carbonitrile, the desired product was isolated as a white solid. LC/MS calcd. for C25H25N5O2 (m/e) 427.5, obsd. 428.1 (M+H, ES+).

Provenance & Evidence