Potassium Permanganate → HCID 59838603, compound

HRID 1754179Notes

Reaction equation

HRID 1754179 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:26]=[C:27]([CH3:29])[CH:28]=1)[C:5]([N:7]([C:21]([CH3:25])([CH3:24])[CH:22]=[O:23])[NH:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[C:11]=1[CH2:18][CH3:19])=[O:6].[O-:30][Mn](=O)(=O)=O.[K+].[OH-].[Na+].CCO>>[CH3:29][C:27]1[CH:26]=[C:4]([CH:3]=[C:2]([CH3:1])[CH:28]=1)[C:5]([N:7]([C:21]([CH3:24])([CH3:25])[C:22]([OH:30])=[O:23])[NH:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[C:11]=1[CH2:18][CH3:19])=[O:6]

Participants

4

Reactant 3

HCID 516875Potassium PermanganateHCID 23692425Sodium hydroxide ethanolHCID 59838597HCID 59838597, compound

Product 1

HCID 59838603HCID 59838603, compound

Procedure

2-[N-(3,5-Dimethyl-benzoyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazino]-2-methyl-propionic acid was prepared by oxidation of 2-ethyl-3-methoxy-benzoic acid N′-(3,5-dimethyl-benzoyl)-N′-(1,1-dimethyl-2-oxo-ethyl)-hydrazide with KMnO4. The corresponding ester could not be saponified to the acid shown, even with 40% NaO/CH3OH, or 50% aqueous NaOH+EtOH with reflux.

Workup

  1. temperaturewith reflux

Sources & evidence

ORD record
ord-2eec3211fa2246dba55e6862f71d15ca
Source dataset
uspto-grants-2015_10
Patent number
US09169210B2

Reaction notes

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