Hydrochloric Acid → 1-(3,4-Dibromo-benzyl)-piperazine

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Reaction Steps

A suspension of 4-(3,4-dibromo-benzyl)-piperazine-1-carboxylic acid tert-butyl ester (6.0 g) in MeOH (100 mL) was treated with 2 M HCl in Et2O (28 mL). After 16 h, the resulting suspension was diluted with Et2O (100 mL) and filtered. The solid was washed with Et2O (2×20 mL) and dried in vacuo, giving a white solid (5.0 g). This solid was partitioned between 10% aq. KOH (50 mL) and DCM (3×50 mL). The combined organic extracts were dried (MgSO4) and concentrated to give the title compound as a colorless glassy oil.

Provenance & Evidence