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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1754221Generated: October 25, 2026

Piperonal → 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-fluorophenyl)piperazine-1-carboxamide

https://huagongshe.com/reaction/1754221

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperonalHCID 8438—
ReactantN-(4-Fluorophenyl)piperazine-1-carboxamideHCID 16228149—
Product4-(1,3-benzodioxol-5-ylmethyl)-N-(4-fluorophenyl)piperazine-1-carboxamideHCID 1079407—

Reaction Steps

The title compound was prepared from piperazine-1-carboxylic acid (4-fluoro-phenyl)-amide and piperonal. 1H NMR (400 MHz, CDCl3): 7.29-7.24 (m, 2H), 6.98-6.92 (m, 2H), 6.85 (s, 1H), 6.77-6.71 (m, 2H), 6.56 (s, 1H), 5.95 (s, 2H), 3.50-3.45 (m, 6H), 2.45 (t, J=5.1 Hz, 4H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09169224B2
Source datasetuspto-grants-2015_10
ORD IDord-8b2bd862696242459820e8518ecf6d40
Source noteuspto-grants-2015_10