Ethyl orthoformate → HCID 86723570, compound

Participants

Reaction Steps

(S)-4-bromo-N-(1,1,1-trifluoropropan-2-yl)thiazole-2-carbohydrazonamide (55 g,) in triethoxymethane (500 ml) was stirred at 90 OC for 3 hours and then at 130° C. overnight and the reaction was concentrated. The residue was purified by column to obtain (S)-4-bromo-2-(4-(1,1,1-trifluoropropan-2-yl)-4H-1,2,4-triazol-3-yl)thiazole. 1HNMR (400 MHz, CDCl3): δ 8.46 (1H, s), 7.43 (1H, s), 6.48-6.52 (1H, m), 1.83 (3H, d, J=7.2 Hz).

Provenance & Evidence