Hydrochloride methanol → HCID 118222066, compound

HRID 1754292Notes

Reaction equation

HRID 1754292 reaction equation
[OH:1][CH:2]1[CH2:8][O:7][CH:6]([CH3:9])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.Cl.CO>CO>[CH3:9][CH:6]1[CH2:5][NH:4][CH2:3][CH:2]([OH:1])[CH2:8][O:7]1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 118222048HCID 118222048, compound

Product 1

HCID 118222066HCID 118222066, compoundYield 137.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
30 °C

Procedure

To a mixture of tert-butyl 6-hydroxy-2-methyl-1,4-oxazepane-4-carboxylate (D1, 494.00 mg, 2.14 mmol, 1.00 eq) in MeOH (5.00 mL), was added HCl/MeOH (15.00 mL) in one portion at 30° C. under N2. The mixture was stirred at 30° C. for 5 hours. TLC showed the reaction was completed. The mixture was concentrated in vacuum to afford 2-methyl-1,4-oxazepan-6-ol (385.00 mg, crude) as yellow oil.

Workup

  1. concentrationThe mixture was concentrated in vacuum

Sources & evidence

ORD record
ord-758d46de498b4a25aa29d9a214ba175a
Source dataset
uspto-grants-2015_10
Patent number
US09169212B2

Reaction notes

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