反应详情

A methanol (12 ml) solution of potassium hydroxide (1.26 g, 22.5 mol) was put into a tetrahydrofuran (50 ml) solution of methyl 4-bromo-2-tert-butyl-5-phenyl-1-benzofuran-7-carboxylate (I-255) (2.90 g, 7.49 mmol), followed by stirring at room temperature for 3.5 hours. The reaction liquid was concentrated under reduced pressure, then 1 N hydrochloric acid (100 ml) and water (100 ml) were added, the product was extracted with ethyl acetate (200 ml×2). The organic layer was washed with saturated brine (50 ml×2), then dried over anhydrous magnesium sulfate, concentrated under reduced pressure to obtain the entitled compound (2.64 g, 95%) as a yellow white solid.

1. customThe reaction liquid
2. concentrationwas concentrated under reduced pressure
3. addition1 N hydrochloric acid (100 ml) and water (100 ml) were added
4. extractionthe product was extracted with ethyl acetate (200 ml×2)
5. washThe organic layer was washed with saturated brine (50 ml×2)
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure