1,4-Dioxane hydrochloride → HCID 86720265, compound

Participants

Reaction Steps

(S)—((R)-quinuclidin-3-yl) 2-(tert-butoxycarbonylamino)-2-phenylacetate (0.618 g, 1.715 mmol) was dissolved in THF (6 ml). HCl/dioxane 4M (3 ml, 1.715 mmol) was added, and the reaction was stirred at RT for 30 minutes. The precipitate was filtered, washed with Et2O (10 ml) and dried at RT to give (S)—((R)-quinuclidin-3-yl) 2-amino-2-phenylacetate dihydrochloride (550 mg, 1.65 mmol).

Provenance & Evidence