Hydrochloric Acid → HCID 86720268, compound

Participants

Reaction Steps

To a stirred solution of (S)-4-(2-((1-(tert-butoxycarbonyl)azetidine-3-carbonyl)oxy)-2-(3,4-dimethoxyphenyl)ethyl)-3,5-dichloropyridine 1-oxide (105 mg, 0.2 mmol) in ethyl acetate (0.5 mL) was added a 2M solution of HCl in diethyl ether (1.5 mL, 3 mmol). The mixture was allowed to stir at room temperature for 4 hours and then acetonitrile (5 mL) was added. The mixture was allowed to stir at room temperature for 3 hours. The solid was removed by filtration, washed with diethyl ether and dried to afford the title compound as a yellow solid (93 mg, 95%).

Provenance & Evidence