Sodium Bicarbonate → HCID 86720279, compound

Participants

Reaction Steps

To a vigorously stirred solution of 4-formylbenzenesulfonyl chloride (1 g, 5 mmol) in DCM (10 mL), was added saturated aqueous sodium bicarbonate solution (10 mL), followed by tert-butyl(2S)-pyrrolidine-2-carboxylate (856 mg, 5 mmol). The organic phase was passed through a hydrophobic frit, and the solvent was removed in vacuo. The crude material was purified by silica gel column chromatography, eluting with 0-100% EtOAc in isohexane, to afford the title compound as a colourless gum (849 mg, 60%).

Provenance & Evidence