2,6-Difluoroaniline → 4-bromo-N-(2,6-difluorophenyl)-3-methylthiophene-2-carboxamide

To a 0° C. solution of 2,6-difluoroaniline (1.10 g, 8.58 mmol, 1.0 eq) in DCM (20 mL) was added drop wise trimethyl aluminium (2 M in toluene, 4.3 mL, 1.0 eq) followed by a solution of methyl-4-bromo-3-methylthiophene-2-carboxylate (2.0 g, 8.58 mmol, 1.0 eq). The reaction was allowed to come to room temperature and then stirred for 2 h at the same temperature. The reaction was quenched with water (10 mL) followed by the addition of DCM (20 mL). The layers were separated, and the organic layer was washed with brine (15 mL), dried (Na2SO4) and filtered. The filtrate was rotary evaporated and the residue was purified by flash column chromatography (silica gel, 30% ethyl acetate in hexane) to afford 1.0 g (35%) of the desired product as a brown solid. 1HNMR (400 MHz, CDCl3) δ 7.42 (s, 1H), 7.28-7.21 (m, 1H), 7.15 (s, 1H, D2O exchangeable), 7.03-6.94 (m, 2H), 2.56 (s, 3H); ESI-MS (m/z) 332, 334 [(MH)+, Br79,81].

1. customto come to room temperature
2. customThe reaction was quenched with water (10 mL)
3. additionfollowed by the addition of DCM (20 mL)
4. customThe layers were separated
5. washthe organic layer was washed with brine (15 mL)
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. customThe filtrate was rotary evaporated
9. customthe residue was purified by flash column chromatography (silica gel, 30% ethyl acetate in hexane)

ORD record

ord-639221bbc3dc4b1ea9000998b5f34a5e

Source dataset

uspto-grants-2015_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09169242B2