4-Amino-2-(trifluoromethyl)benzonitrile → 4-Cyano-3-(trifluoromethyl)benzene-1-sulfonyl chloride

HRID 1754528Notes

Reaction equation

HRID 1754528 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.N[C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[C:17]([C:23]([F:26])([F:25])[F:24])[CH:16]=1>>[C:19]([C:18]1[CH:21]=[CH:22][C:15]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:16][C:17]=1[C:23]([F:26])([F:25])[F:24])#[N:20]

Participants

3

Reactant 2

HCID 5221704-Amino-2-(trifluoromethyl)benzonitrileHCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 545924284-Cyano-3-(trifluoromethyl)benzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 4-amino-2-trifluoromethyl-benzonitrile.

Sources & evidence

ORD record
ord-6a23076d353646a4b5752b219fafe860
Source dataset
uspto-grants-2015_10
Patent number
US09169251B2

Reaction notes

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