4-Chloro-3-(trifluoromethyl)aniline → 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride

HRID 1754534Notes

Reaction equation

HRID 1754534 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.[Cl:14][C:15]1[CH:20]=[CH:19][C:18](N)=[CH:17][C:16]=1[C:22]([F:25])([F:24])[F:23]>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:17][C:16]=1[C:22]([F:25])([F:24])[F:23]

Participants

3

Reactant 2

HCID 675744-Chloro-3-(trifluoromethyl)anilineHCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 27807194-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 4-chloro-3-trifluoromethyl-phenylamine.

Sources & evidence

ORD record
ord-ff5e3662d48443e0a9fbbaee6c81b3a6
Source dataset
uspto-grants-2015_10
Patent number
US09169251B2

Reaction notes

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