Sodium t-butoxide → HCID 86712751, compound

Participants

Reaction Steps

65 mg of (R)-tert-butyl 9-chloro-1-(pyrrolidine-2-carbonyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate was stirred together with 1.8 mg of 2′-(ditert-butylphosphino)-N,N-dimethylbiphenyl-2-amine, 2.5 mg Pd2(dba)3 and 19 mg sodium 2-methylpropan-2-olate at 100° C. over 10 hours in toluene. The reaction mixture was then cooled to room temperature and evaporated. The residue was purified by column chromatography on silica (eluent: 10-25% ethyl acetate in heptane) to yield 20 mg of the title compound as a beige solid.

Provenance & Evidence