HCID 89453705, compound → HCID 178505003, compound

HRID 1754575Notes

Reaction equation

HRID 1754575 reaction equation
[O:1]=[C:2]1[C:11]2[CH2:12][NH:13][N:14](COCC[Si](C)(C)C)[C:10]=2[C:9]2[CH:8]=[CH:7][C:6]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:5][C:4]=2[N:3]1[CH2:34][C:35]([F:38])([F:37])[F:36].O=C1C2=CN(COCC[Si](C)(C)C)N=C2C2C=CC(C3C=CC=CC=3NS(C)(=O)=O)=CC=2N1CC(F)(F)F>>[O:1]=[C:2]1[C:11]2=[CH:12][NH:13][N:14]=[C:10]2[C:9]2[CH:8]=[CH:7][C:6]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:5][C:4]=2[N:3]1[CH2:34][C:35]([F:36])([F:37])[F:38]

Participants

3

Reactant 2

HCID 89453705HCID 89453705, compoundHCID 89454421HCID 89454421, compound

Product 1

HCID 178505003HCID 178505003, compoundYield 74%

Procedure

The product is obtained according to the procedure described in Step 4.3. starting with N-{2-[4-oxo-5-(2,2,2-trifluoroethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-dihydro-2H-pyrazolo[4,3-c]quinolin-7-yl]phenyl}methanesulfonamide and N-{2-[4-oxo-5-(2,2,2-trifluoroethyl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-dihydro-2H-pyrazolo[4,3-c]quinolin-7-yl]phenyl}methanesulfonamide, in the form of a white powder (yield 74%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-7564eebf23cb4dbd9726b84c015bf55d
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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