Triphenylphosphine → HCID 46936097, compound

Participants

Reaction Conditions

Reaction Steps

To azido-bis[4-(12-docosoxydodecyloxy)phenyl]methane (72.0 mg, 58.7 μmol) were added toluene (2 ml), purified water (2 ml) and triphenylphosphine (29 mg, 110 μmol) and the mixture was vigorously stirred at 45° C. for 3 hr and 60° C. for 3.5 hr. The reaction mixture was cooled to room temperature, and 10% aqueous sodium hydrogen carbonate (2 ml) was added. After stirring for a while, toluene (8 ml) was added and the aqueous layer was discarded. The organic layer was washed with purified water (10 ml)×2. The organic layer was evaporated under reduced pressure, and the residue was crystallized from acetonitrile, and the obtained crystals were washed with purified water to give amino-bis[4-(12-docosoxydodecyloxy)phenyl]methane (44 mg, 36.5 μmol, 62%).

Provenance & Evidence