Dimethylamine → HCID 90022178, compound

Participants

Reaction Steps

A solution of (±)-2-bromo-4-(2-carboxymethoxy-5-chloro-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid benzyl ester (21 mg, 0.04 mmol, 1.0 eq.) in 2M dimethylamine in THF (0.5 mL) was heated at 80° C. for 18 hours. The reaction mixture was allowed to cool to r.t. and concentrated in vacuo. The residue was taken up in DMF, filtered, and purified by prep. HPLC (column: Atlantis, 30×75 mm, 10 um, UV/MS, acidic conditions) and concentrated in vacuo to give the title compound as a white solid.

Provenance & Evidence