Phosphorus oxychloride → HCID 90022223, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of {4-chloro-2-[2-(2-isopropyl-thiazol-4-yl)-ethylcarbamoyl]-phenoxy}-acetic acid ethyl ester (100 mg, 0.24 mmol, 1 eq.) and POCl3 (0.34 mL, 3.65 mmol, 15 eq.) in MeCN (2 mL) was stirred at 80° C. for 18 hours. The mixture was allowed to cool down to r.t. and concentrated in vacuo. The residue was purified by prep. HPLC (column: Atlantis, 30×75 mm, 10 um, UV/MS, acidic conditions) and concentrated in vacuo to give ethyl 2-(4-chloro-2-(2-isopropyl-6,7-dihydrothiazolo[5,4-c]pyridin-4-yl)phenoxy)acetate as a yellow oil.

Provenance & Evidence