HCID 66817087, compound → HCID 66818076, compound

HRID 1754919Notes

Reaction equation

HRID 1754919 reaction equation
[CH:1]1([C:7]2[NH:11][C:10](=[O:12])[C:9]3([CH2:17][CH2:16][N:15]([S:18]([CH2:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([N+:29]([O-])=O)[CH:24]=4)(=[O:20])=[O:19])[CH2:14][CH2:13]3)[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[Pd]>[NH2:29][C:25]1[CH:24]=[C:23]([CH2:22][CH2:21][S:18]([N:15]2[CH2:14][CH2:13][C:9]3([N:8]=[C:7]([CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[NH:11][C:10]3=[O:12])[CH2:17][CH2:16]2)(=[O:20])=[O:19])[CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 1

HCID 66817087HCID 66817087, compound

Product 1

HCID 66818076HCID 66818076, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd—C (1 g) was added to a solution of Compound 18d (1 g, 2.23 mmol) in ethanol (10 ml), and the mixture was stirred at room temperature for two days in an H2 atmosphere. The reaction mixture was filtered, and the filtrate was then concentrated under reduced pressure to give 8-[2-(3-amino-phenyl)-ethanesulfonyl]-2-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-1-en-4-one (920 mg, 98%).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-0087ae2a6ee74189a62bdb3511e5027d
Source dataset
uspto-grants-2015_10
Patent number
US09169254B2

Reaction notes

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