Tetrabutylammonium Fluoride → HCID 66816812, compound

Participants

Reaction Steps

Tetrabutylammonium fluoride (0.11 ml, 0.11 mmol, 1 M in THF) was added to a solution of 8-((E)-2-{3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-2-methyl-phenyl}-ethenesulfonyl)-2-(3-trifluoromethoxy-phenyl)-1,3,8-triaza-spiro[4.5]dec-1-en-4-one obtained above in anhydrous THF (1 ml) at room temperature in an Ar atmosphere. The mixture was stirred at room temperature for two hours and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:EtOAc=1:1) to give 8-{(E)-2-[3-(2-hydroxy-ethoxy)-2-methyl-phenyl]-ethenesulfonyl}-2-(3-trifluoromethoxy-phenyl)-1,3,8-triaza-spiro[4.5]dec-1-en-4-one (3.2 mg, yield in two steps: 48%).

Provenance & Evidence