HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Bromo-5-isocyanato-1,3-dimethylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 4-Bromo-3,5-dimethylaniline | HCID 12383117 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Bromo-5-isocyanato-1,3-dimethylbenzene | HCID 86672765 | 117.6% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Triphosgene (2.23 g, 7.52 mmol) was added to a solution of 4-bromo-3,5-dimethyl-phenylamine (4.3 g, 21.49 mmol) in dioxane (71 ml). After stirring at 100° C. for 15 hours, water was added to the reaction solution. After extraction with ethyl acetate, the organic phase was sequentially washed with water and saturated brine and concentrated under reduced pressure to give 2-bromo-5-isocyanato-1,3-dimethylbenzene (2.0 g, 41%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169254B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-fb602089dde1444fa16869f3eea4d148 |
| Source note | uspto-grants-2015_10 |