HCID 66817420, compound → HCID 66816725, compound

Participants

Reaction Steps

20% Pd(OH)2—C (30 mg) was placed into a solution of N-(3-methoxy-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-ene-8-sulfonyl]-vinyl}-phenyl)-acetamide (31 mg, 0.0617 mmol) in methanol (5 ml), and the atmosphere was replaced with hydrogen. The mixture was stirred at room temperature for 16 hours. The reaction mixture was filtered, and the filtrate was then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (dichloromethane-ethyl acetate) to give N-(3-methoxy-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-ene-8-sulfonyl]-ethyl}-phenyl)-acetamide (20 mg).

Provenance & Evidence