Sodium Methoxide → HCID 66818053, compound

Participants

Reaction Steps

A 2 M solution of sodium methoxide in methanol (4 ml, 8 mmol) was added to a solution of ethyl 2-[N-(4-bromo-3,5-dimethyl-phenyl)-N-sulfamoyl-amino]-2-methyl-propanoate (100 mg, 0.254 mmol) in methanol (12 ml), and the mixture was irradiated with microwaves at 65° C. for 10 minutes. The reaction mixture was diluted with ethyl acetate, and the organic layer was sequentially washed with water and saturated brine and concentrated under reduced pressure to give 5-(4-bromo-3,5-dimethyl-phenyl)-4,4-dimethyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-3-one (80 mg, 90%).

Provenance & Evidence