Potassium Cyanide → HCID 66817117, compound

Participants

Reaction Conditions

Reaction Steps

Ammonium acetate (686 mg, 8.91 mmol) and potassium cyanide (541 mg, 8.31 mmol) were added to a solution of 1-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethenesulfonyl]-piperidin-4-one (1.91 g, 5.94 mmol) in MeOH (20 ml), and the mixture was heated with stirring at 60° C. for three hours. The mixed reaction solution was cooled and a saturated aqueous NaHCO3 solution was then added, followed by extraction with ethyl acetate. The organic layer was sequentially washed with water and saturated brine, and then dried over Na2SO4 and concentrated under reduced pressure. The resulting residue was triturated with hexane:CH2Cl2=7:3 to give 4-amino-1-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethenesulfonyl]-piperidine-4-carbonitrile (1.86 g, 89%).

Provenance & Evidence