Sodium Thiosulfate → HCID 66818288, compound

Participants

Reaction Steps

Dess-Martin reagent (151 mg, 0.355 mmol) was added to a solution of 4-(1-hydroxy-ethyl)-cyclohexanecarboxylic acid benzyl ester (71.6 mg, 0.273 mmol) in anhydrous dichloromethane (0.91 ml) at 0° C. The mixture was stirred at the same temperature for 10 minutes, and further warmed to room temperature and stirred for 4.5 hours. An aqueous sodium thiosulfate solution was added to the reaction solution, followed by extraction with dichloromethane. The organic phase was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give 4-acetyl-cyclohexanecarboxylic acid benzyl ester (60.2 mg, 85%).

Provenance & Evidence