Ethyl 7-bromoheptanoate → HCID 86672786, compound

Participants

Reaction Steps

0.5 M sodium ethoxide (1.6 ml, 4.31 mmol) was added to a solution of ethyl 7-bromoheptanoate (300 mg, 1.44 mmol) in ethanol (7.0 ml), and the mixture was heated under reflux for two hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was then purified by silica gel column chromatography (hexane:ethyl acetate=10:1) to give ethyl 7-ethoxyheptanoate (102.4 mg, 40%).

Provenance & Evidence