1,1,1-Trifluoro-2-methylpropan-2-ol → HCID 87166588, compound

HRID 1755084Notes

Reaction equation

HRID 1755084 reaction equation
CC(C)([O-])C.[K+].[Br:7][C:8]1[CH:9]=[CH:10][C:11](F)=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1.[F:19][C:20]([F:26])([F:25])[C:21]([OH:24])([CH3:23])[CH3:22]>CN1C(=O)N(C)CC1>[Br:7][C:8]1[CH:9]=[CH:10][C:11]([O:24][C:21]([CH3:23])([CH3:22])[C:20]([F:26])([F:25])[F:19])=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1

Participants

5

Reactant 3

HCID 681821,1,1-Trifluoro-2-methylpropan-2-olHCID 27363255-Bromo-2-fluorobenzotrifluorideHCID 23665647Potassium tert-butoxide

Product 1

HCID 87166588HCID 87166588, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 66611,3-Dimethyl-2-imidazolidinoneSolvent

Conditions

Temperature
100 °C

Procedure

Potassium tert-butoxide (236 mg, 2.1 mmol) was added to a solution of 5-bromo-2-fluorobenzotrifluoride (485 mg, 2.0 mmol) and 2-trifluoromethyl-2-propanol (0.24 mL, 2.2 mmol) in DMI (0.5 mL) at room temperature, and the mixture was stirred at 100° C. for two hours. The reaction solution was purified by silica gel column chromatography to give 4-bromo-1-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-2-trifluoromethyl-benzene (349 mg, 50%).

Workup

  1. customThe reaction solution was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-f63e094f0d9144aba92ebd7a96c89c87
Source dataset
uspto-grants-2015_10
Patent number
US09169254B2

Reaction notes

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