Methyl morpholine oxide → HCID 86672793, compound

Participants

Reaction Steps

NMO (22.0 mg, 0.192 mmol), Molecular Sieves 4A (25.0 mg) and TPAP (0.700 mg, 0.00213 mmol) were added to a solution of 1-(4-{2-[2-(9-hydroxy-nonyl)-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-ene-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-1-methyl-urea (24.0 mg, 0.0426 mmol) in CH2Cl2 (850 μl) at room temperature. The mixture was stirred at room temperature for one hour and then filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 1-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(9-oxo-nonyl)-1,3,8-triaza-spiro[4.5]dec-1-ene-8-sulfonyl]-vinyl}-phenyl)-1-methyl-urea (17.0 mg, 71%).

Provenance & Evidence