N-Methyl dicyclohexylamine → HCID 66817656, compound

Participants

Reaction Conditions

Reaction Steps

Dicyclohexyl-methyl-amine (34.2 ml, 162.8 mmol) was added to a solution of 8-ethenesulfonyl-1,4-dioxa-8-aza-spiro[4.5]decane (17.3 g, 74.01 mmol), 4-bromo-3-methyl-benzoic acid (19.1 g, 88.82 mmol), Pd(dba)2 (4.26 g, 7.40 mmol) and tri-t-butylphosphonium tetrafluoroborate (2.15 g, 7.40 mmol) in NMP (70.0 ml), and the mixture was stirred at 100° C. for one hour in a nitrogen atmosphere. The reaction solution was cooled to room temperature and then diluted with ethyl acetate, and the organic layer was washed with a 1 M aqueous hydrochloric acid solution and saline. The organic layer was allowed to stand for a while, and the precipitated solid was filtered off. The resulting solid was washed with ethyl acetate to give 4-[(E)-2-(1,4-dioxa-8-aza-spiro[4.5]decane-8-sulfonyl)-vinyl]-3-methyl-benzoic acid as a gray solid (25.6 g, 94.1%).

Provenance & Evidence