Potassium Cyanide → HCID 66818447, compound

Participants

Reaction Conditions

Reaction Steps

Potassium cyanide (382 mg, 5.87 mmol) and ammonium acetate (513 mg, 6.65 mmol) were added to a solution of N-(2-allyloxy-ethyl)-3,N-dimethyl-4-[2-(4-oxo-piperidine-1-sulfonyl)-ethyl]-benzamide (1.65 g, 3.91 mmol) in methanol (20 ml), and the mixture was stirred at 65° C. for three hours. Sodium bicarbonate (290 mg) was added to the reaction solution, and the mixture was then concentrated under reduced pressure. Water was added to the resulting residue, followed by extraction with methylene chloride. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give N-(2-allyloxy-ethyl)-4-[2-(4-amino-4-cyano-piperidine-1-sulfonyl)-ethyl]-3,N-dimethyl-benzamide (1.57 g) as a crude compound.

Provenance & Evidence